![]() ![]() Full siblings of cancer patients have a 25% chance of being HLA matched.Įarly serologic techniques of HLA assessment defined a number of HLA antigens, but more precise DNA methodologies have shown HLA allele-level mismatches in up to 40% of serologic HLA antigen matches. HLA class I (A, B, C, etc.) and class II (DRB1, DRB3, DRB4, DRB5, DQB1, DPB1, etc.) alleles are highly polymorphic therefore, finding appropriately matched unrelated donors is a challenge for some patients, especially those of certain racial groups (e.g., patients with African, Hispanic, Asian, or Pacific-Islander ancestry). The locations of specific HLA loci for the class I B, C, and A alleles and the class II DP, DQ, and DR alleles are shown. Human chromosome 6 with amplification of the HLA region. Other Donor Characteristics Associated With OutcomeĪppropriate matching between donor and recipient HLA in the major histocompatibility complex located on chromosome 6 is essential to successful allogeneic hematopoietic stem cell transplantation (HSCT) (see Figure 1, Table 1, and Table 2).Įnlarge Figure 1.HLA Matching and Cell Dose Considerations for Unrelated Cord Blood HSCT.HLA Matching Considerations for Unrelated Donors.HLA Matching Considerations for Sibling and Related Donors.Īllogeneic Hematopoietic Stem Cell Transplantation (HSCT) Indications for Hematologic Malignancies Majhail NS, Chitphakdithai P, Logan B, et al.: Significant improvement in survival after unrelated donor hematopoietic cell transplantation in the recent era.Harvey J, Green A, Cornish J, et al.: Improved survival in matched unrelated donor transplant for childhood ALL since the introduction of high-resolution matching at HLA class I and II.Biol Blood Marrow Transplant 14 (9 Suppl): 16-22, 2008.
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